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American College of Cardiology / American Heart Association

American College of Cardiology / American Heart Association

Medical Professional Societies

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Statins and the evidence gap

New Capabilities

Issued 2026 dyslipidemia guidelines endorsing earlier statin use

More than 200 million people worldwide take statins for heart health. For decades, package inserts have warned about 66 potential side effects, from memory loss to depression to muscle pain. The February 2026 Lancet analysis of 23 major clinical trials with nearly 155,000 participants found 62 of those warnings unsupported by evidence, with symptoms appearing equally in statin and placebo groups.

Updated Mar 19