Spanish National Cancer Research Centre (CNIO)

New Capabilities

Conducting preclinical research, seeking path to human trials

For 40 years, the KRAS gene has been oncology's white whale—present in 90% of pancreatic cancers, yet resistant to every drug thrown at it. Scientists called it 'undruggable.' On January 28, 2026, Spanish researchers published results showing they had achieved what decades of effort could not: complete and lasting tumor elimination in mice using a triple-drug combination that blocks KRAS and two downstream pathways simultaneously.

Updated Jan 30