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Intellia Therapeutics

Intellia Therapeutics

Clinical-stage biotechnology company

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Intellia releases first Phase 3 readout for an in-body CRISPR therapy

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Sponsor of HAELO; planning 2026 BLA filing

For decades, people with hereditary angioedema have lived with weekly injections, infusions, or pills to suppress unpredictable swelling attacks that can close off the airway. Intellia Therapeutics released topline data on April 27, 2026 from HAELO, a global Phase 3 trial of lonvoguran ziclumeran (lonvo-z) — the first late-stage clinical readout ever for an in-body CRISPR gene-editing therapy.

Updated 3 hours ago