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Karolinska Institutet

Karolinska Institutet

Research university

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GLP-1 weight-loss drugs show unexpected psychiatric benefits in largest study to date

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Co-produced the March 2026 study

Drugs originally designed to control blood sugar and reduce weight may also protect the brain. A study of 95,490 people in Sweden, published in The Lancet Psychiatry on March 22, 2026, found that semaglutide (the compound in Ozempic and Wegovy) reduced psychiatric hospitalizations, worsening depression, and substance-use crises.

Updated May 30