National Institute of Diabetes and Digestive and Kidney Diseases

New Capabilities

Lead institution on the May 2026 Nature Metabolism study

Patients on Ozempic and Wegovy typically lose about 15% of their body weight, then stall around 14 months in. On May 25, NIH researchers in Nature Metabolism reported what may be happening inside the brain to cause that stall, and a way to keep the drug working longer.

Updated May 25