Research University and Medical Center
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Provided in vivo testing in transgenic mouse models
For two decades, lowering LDL cholesterol meant statins—pills taken daily that work, but leave one in five patients with muscle aches, liver enzyme spikes, or symptoms severe enough to quit. Researchers at the University of Barcelona and University of Oregon now report a different approach: a short, engineered DNA molecule that silences the gene controlling how the liver clears LDL, dropping cholesterol by nearly 50 percent in mice from a single injection.
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