Director, Jenner Institute; Professor of Vaccinology, University of Oxford
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Led development of R21/Matrix-M, the first vaccine to hit 75% efficacy
NIH researchers discovered a new class of antibodies that attack malaria parasites at a never-before-targeted site. The antibody MAD21-101 protected four out of five mice from infection, working differently than existing vaccines by binding to a cryptic protein fragment exposed only after the parasite undergoes pyroglutamylation, a specific chemical transformation. This opens a fresh avenue in the decades-long hunt for a highly effective malaria vaccine.
Updated May 19
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