French physician who first used metformin to treat diabetes
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Deceased
More than 150 million people take metformin every year to manage Type 2 diabetes. Doctors have prescribed it since 1957, and for most of that time, the consensus was that it works primarily in the liver and gut. A team at Baylor College of Medicine has now shown that at clinically relevant low doses, metformin actually lowers blood sugar by deactivating a protein called Rap1 in a specific cluster of brain neurons — the ventromedial hypothalamus — that acts as a metabolic control center.
Updated 4 hours ago
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