French physician who first used metformin to treat diabetes
Appears in 1 story
Deceased
More than 150 million people take metformin every year to manage Type 2 diabetes. Doctors prescribed it starting in 1957, and for most of that time, assumed it worked primarily in the liver and gut. A Baylor team found that at clinically relevant low doses, the drug deactivates Rap1 in the ventromedial hypothalamus—a brain region controlling metabolism.
Updated May 30
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