Jian Ma

Co-led the study; professor, Ray and Stephanie Lane Computational Biology Department, Carnegie Mellon

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Last updated Sep 13, 2026

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Alzheimer's disrupts the 3D folding of DNA in brain cells

New Capabilities

As of September 2026: Built the Hicformer AI model with his group

Alzheimer's disease scrambles the three-dimensional folding of DNA inside brain cells, a study published in Science on July 23 reports. It's the first single-cell map of how the disease reshapes the genome's architecture across the brain.

Updated Sep 13