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Michael Kharas

Michael Kharas

Cancer biologist, Memorial Sloan Kettering Cancer Center

Appears in 1 story

Notable Quotes

"It's remarkable that such a small change can have such a large effect." β€” on the protective variant discovery

"Musashi-2 is required for cancer stem cells to survive. When [our inhibitor] was added to AML cells in a dish, the cells became normal." β€” on therapeutic potential

Stories

MSI2 protective variant against blood cancer discovered

New Capabilities

Co-corresponding author of the Science paper

For decades, cancer genetics meant finding mutations that raise risk. Now scientists have found one that lowers it. A variant in the MSI2 gene reduces the risk of blood cancers by up to 30% in people who carry two copiesβ€”the first protective genetic variant identified against myeloid malignancies.

Updated 7 days ago