Nicole La Gruta

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Aging-linked protein drives organ damage in mice without weakening immunity

Leading follow-up work on blocking granzyme K

A protein produced by aging immune cells appears to damage the heart, liver and kidneys as mice grow old. When researchers removed granzyme K from aged mice, all three organs held up better. The animals' immune systems still aged on schedule.

Updated 2 hours ago

Notable Quotes

"What's particularly exciting is that mice without this protein showed reduced signs of organ aging, even though their immune systems continued to age normally."

from Aging-linked protein drives organ damage in mice without weakening immunity · Updated 2 hours ago

"Because these mice have lived their entire lives without granzyme K, we now need to understand whether blocking the protein later in life could achieve similar benefits."

from Aging-linked protein drives organ damage in mice without weakening immunity · Updated 2 hours ago