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Pascal Geldsetzer

Pascal Geldsetzer

Assistant Professor of Medicine, Stanford University

Appears in 1 story

Notable Quotes

"The most exciting part is that this really suggests the shingles vaccine doesn't have only preventive, delaying benefits for dementia, but also therapeutic potential for those who already have dementia."

Stories

The vaccine that might prevent dementia

New Capabilities

Lead researcher on dementia progression study

A shingles vaccine is showing up in dataset after dataset as a dementia preventer. Oxford researchers published results in Nature Medicine in July 2024 showing Shingrix—the recombinant shingles vaccine—cuts dementia risk by 17-20% compared to unvaccinated people. Stanford followed with a Cell study in December 2024 showing it might even slow progression in people already diagnosed, cutting dementia death risk by 29.5 percentage points. Then in April 2025, Geldsetzer's team published in Nature showing causal evidence from a natural experiment in Wales. By July 2025, GSK was presenting data at the Alzheimer's Association International Conference showing risk reductions as high as 51% in Southern California populations.

Updated Feb 2