Sonia Vazquez-Sanchez

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Huntington's cortical neuron loss linked to large somatic DNA repeat expansions

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Huntington's disease has long been framed as a protein problem: mutant huntingtin clumps inside neurons and kills them. A new Cell study maps 428,173 cortical cells and finds that the neurons most likely to die carry extreme somatic expansions of the CAG repeat, beyond 450 repeats.

Updated 3 hours ago