Steve McCarroll

Geneticist, Broad Institute and Harvard Medical School; senior author of companion paper

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Education: University of California, San Francisco, Stanford University

Last updated Nov 2, 2026

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Huntington's cortical neuron loss linked to large somatic DNA repeat expansions

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Huntington's disease has long been framed as a protein problem: mutant huntingtin clumps inside neurons and kills them. A new Cell study maps 428,173 cortical cells and finds that the neurons most likely to die carry extreme somatic expansions of the CAG repeat, beyond 450 repeats.

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