Publicly traded biotechnology company
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Developer of barzolvolimab; plans BLA submission in 2027
Celldex's experimental antibody barzolvolimab beat placebo in two Phase 3 trials for chronic spontaneous urticaria, the condition behind recurring hives and severe itching. Roughly 42% to 46% of treated patients were completely symptom-free at 12 weeks, versus about 10% on placebo. The drug works by depleting the mast cells that drive the disease—a mechanism no approved CSU therapy uses.
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