Bill & Melinda Gates Foundation

The largest private contributor to global polio eradication, having committed nearly $5 billion to the effort. - Largest private funder of polio eradication

When the Global Polio Eradication Initiative launched in 1988, wild poliovirus paralyzed 350,000 children annually across 125 countries. Today, the disease survives in only two: Pakistan and Afghanistan. Pakistan's nationwide vaccination campaign from February 2-8, 2026, reached 44.3 million of 45 million targeted children under five across 159 districts—achieving over 98% coverage in the final push to eliminate a disease that would become only the second human pathogen ever eradicated, after smallpox.

Updated Feb 13

Largest private funder of malaria research and vaccine development globally. - Pledged $912M for 2026-2028; aims to eradicate malaria by 2045

NIH researchers discovered a new class of antibodies that attack malaria parasites at a never-before-targeted site. The antibody MAD21-101 protected four out of five mice from infection and works differently than existing vaccines, binding to a cryptic protein fragment exposed only after the parasite undergoes a specific chemical transformation called pyroglutamylation. The breakthrough opens a fresh avenue in the decades-long hunt for a highly effective malaria vaccine.

Updated Jan 7