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James McCully

James McCully

Pioneer of autologous mitochondrial transplantation

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Mitochondrial medicine reaches inflection point as new delivery methods and first drug approvals converge

New Capabilities

Active researcher at Boston Children's Hospital

For most of modern medicine's history, diseases caused by defective mitochondria — the structures inside cells that generate energy — have been essentially untreatable. Doctors could manage symptoms, but the broken power plants themselves were beyond reach. Now, within a six-month span, the United States Food and Drug Administration (FDA) has approved the first two drugs targeting mitochondrial diseases, and a Chinese research team has demonstrated a method to physically transplant healthy mitochondria into diseased cells with sixteen times the efficiency of previous approaches.

Updated 3 hours ago