Researcher, body composition analysis
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More than 30 million Americans now take GLP-1 receptor agonist drugs like Ozempic and Wegovy to lose weight. A persistent concern has dogged the medications since their rise: that they burn through muscle along with fat, leaving patients weaker even as they get thinner. A study published in Cell Reports Medicine in March 2026 found that while GLP-1 drugs do reduce lean body mass, the rate of muscle loss is not disproportionate to what occurs with diet and exercise alone — and crucially, patients' actual strength remained unchanged.
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