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Nidhi Bhutani

Nidhi Bhutani

Associate Professor of Orthopaedic Surgery, Stanford

Appears in 1 story

Notable Quotes

Millions of people suffer from joint pain and swelling as they age. It is a huge unmet medical need. Until now, there has been no drug that directly treats the cause of cartilage loss. But this gerozyme inhibitor causes a dramatic regeneration of cartilage beyond that reported in response to any other drug or intervention.

Stories

Stanford's Gerozyme breakthrough: regrowing cartilage without stem cells

New Capabilities

Co-senior author on breakthrough study

A November 2025 study in Science showed that blocking an enzyme called 15-PGDH regrew cartilage in older mice and in human joint tissue from knee replacement patients. Blocking it shifts cartilage cells from degrading to rebuilding—without stem cells.

Updated Jun 13