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Sara Sdelci

Sara Sdelci

Group Leader and corresponding author, Centre for Genomic Regulation (CRG), Barcelona

Appears in 1 story

Notable Quotes

"Many of these enzymes synthesize essential building blocks of life, and their nuclear localization is associated with DNA repair. Their presence in the nucleus may therefore directly shape how cancer cells respond to genotoxic stress, a hallmark of many chemotherapeutic treatments. It's an entirely new world to explore." — Sara Sdelci, Centre for Genomic Regulation

Stories

Researchers discover a hidden 'mini metabolism' operating directly on human DNA

New Capabilities

Leading ongoing research into chromatin metabolism and cancer

For decades, biologists treated the cell's energy-producing machinery and its DNA-reading machinery as separate systems operating in separate compartments. A study published March 6 in Nature Communications upends that assumption: more than 200 metabolic enzymes, many of them normally associated with energy production in mitochondria, are physically attached to human DNA inside the nucleus. About 7% of all proteins bound to chromatin turn out to be metabolic enzymes, forming what the researchers describe as a 'mini metabolism' within the nucleus itself.

Updated Mar 6