Pull to refresh
Logo
Daily Brief
Following
Why Sign Up
Sara Sdelci

Sara Sdelci

Group Leader and corresponding author, Centre for Genomic Regulation (CRG), Barcelona

Appears in 1 story

Stories

Researchers discover a hidden 'mini metabolism' operating directly on human DNA

New Capabilities

Leading ongoing research into chromatin metabolism and cancer

For decades, biologists treated the cell's energy-producing machinery and its DNA-reading machinery as separate systems operating in separate compartments. A study published March 6 in Nature Communications upends that assumption: more than 200 metabolic enzymes, many of them normally associated with energy production in mitochondria, are physically attached to human DNA inside the nucleus. About 7% of all proteins bound to chromatin turn out to be metabolic enzymes, forming what the researchers describe as a 'mini metabolism' within the nucleus itself.

Updated Mar 6