Pull to refresh
Logo
Daily Brief
Following Why Sign Up
WP

William Pardridge

Professor of Medicine, University of California Los Angeles

Appears in 1 story

Notable Quotes

"The BBB is the single greatest impediment to the development of new therapeutics for the brain. The pharmaceutical industry has spent decades developing powerful new biologic drugs, but the brain is essentially off-limits to these agents." — William Pardridge, published reviews

Stories

First drug engineered to cross the blood-brain barrier wins FDA approval

New Capabilities

Pioneer of the molecular Trojan horse concept

For decades, the blood-brain barrier has blocked nearly all large-molecule drugs from reaching the brain — a biological wall that left most neurological diseases effectively untreatable with modern biologics. On March 25, 2026, the Food and Drug Administration (FDA) approved AVLAYAH, developed by Denali Therapeutics, making it the first drug in history specifically engineered to cross that barrier and deliver a therapeutic enzyme to the central nervous system after a simple intravenous infusion.

Updated 4 hours ago