Xiangmin Xu

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Study maps sweeping brain genome changes between ages 50 and 75

Collaborating on follow-up studies linking genome changes to neural circuit function

The human brain reshapes how it reads its own genome between ages 50 and 75, according to a single-cell study published in Science. The brain's original immune cells decline during that window and are replaced by variants with stronger inflammatory signatures.

Updated 42 minutes ago

Notable Quotes

This study reveals that aging is not simply a gradual decline, but involves coordinated and dynamic remodeling of the immune, vascular, and nervous systems. These findings open the door to the identification of new therapeutic targets aimed at preserving circuit integrity and brain function throughout the lifespan.

from Study maps sweeping brain genome changes between ages 50 and 75 · Updated 42 minutes ago