Amyloid hypothesis for Alzheimer's gains prominence (1992)
John Hardy and Gerald Higgins published the amyloid cascade hypothesis, arguing that accumulation of amyloid-beta protein in the brain triggers Alzheimer's disease.
It became the dominant framework guiding two decades of Alzheimer's drug development.
Most amyloid-targeting drugs failed to slow cognitive decline in late-stage trials, pushing researchers to look at other mechanisms.
This new study offers a complementary view, focusing on immune cell aging and genome structure rather than protein plaques, which may explain why age remains the strongest risk factor.
