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Crinetics Pharmaceuticals files WARN notice for 78 San Diego layoffs

Crinetics Pharmaceuticals files WARN notice for 78 San Diego layoffs

Money Moves San Diego, CA local

The San Diego drugmaker told California officials it plans to cut 78 workers at its Lusk Boulevard site.

3 days ago: Crinetics files WARN notice for 78 San Diego workers

Overview

Updated 1 hour ago

Crinetics Pharmaceuticals filed a WARN notice with California's Employment Development Department on November 3, listing 78 workers at its San Diego headquarters for layoff. The filing is a notice of intent, not proof the jobs have ended.

Under the federal WARN Act, employers with 100 or more workers must give 60 days' notice before a mass layoff. The cut lands in a year when San Diego's biotech cluster has seen repeated WARN filings, from Gossamer Bio's post-trial cuts to Avidity Biosciences' post-acquisition layoffs.

Why it matters

The notice shows a San Diego biotech cutting 78 jobs, adding to a year of layoffs across the region's drug-development cluster.

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Key Indicators

78
Workers affected
Number listed in Crinetics' WARN notice.
60
Federal WARN notice period
Employers must give 60 days' notice before a mass layoff.
1,174
San Diego County WARN workers in 2026
Workers covered by 28 WARN notices filed in the county as of Nov. 5, 2026.

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Organizations Involved

Crinetics Pharmaceuticals
Crinetics Pharmaceuticals
Public biopharmaceutical company
Filed WARN notice for 78 layoffs

San Diego-based drug developer that filed the WARN notice.
California Employment Development Department
California Employment Development Department
State agency
Receives and publishes WARN notices

California agency that collects WARN filings.

Timeline

1 event Latest: 3 days ago

  1. Crinetics files WARN notice for 78 San Diego workers

    Latest Filing

    The company told California's EDD it plans to lay off 78 employees at 6055 Lusk Blvd.

Scenarios

1

Layoffs proceed as scheduled in January

Likely Resolves by Jan 4, 2027

Discussed by: California EDD WARN records

Crinetics follows through on the notice and separates 78 workers at its Lusk Boulevard site. WARN filings are rarely withdrawn after they are published, and the company has not announced a change.

2

Crinetics amends or withdraws the layoff notice

Possible Resolves by Jan 4, 2027

Discussed by: WARN filing process

The company could reduce the number of affected workers or delay the cuts, as sometimes happens when a restructuring plan changes. That would require an amended filing or public statement.

3

Crinetics announces a broader restructuring

Unlikely Resolves by Q2 2027

Discussed by: Biotech sector layoff pattern

A single WARN notice can precede a larger cost-cutting plan. If Crinetics announces additional cuts or a pipeline shift, the story expands beyond 78 workers.

Historical Context

3 moments from history that rhyme with this story — and how they unfolded.

April 2026

Gossamer Bio layoffs (2026)

Gossamer Bio, a San Diego biotech, failed a Phase 3 trial for its lead drug seralutinib. It laid off 65 workers, almost half its staff.

Then

The company cut clinical development staff and senior vice presidents.

Now

Gossamer said it had enough cash to fund operations into early 2027.

Why this matters now

Shows how a trial failure can trigger rapid layoffs in San Diego's biotech cluster.

October 2026

Avidity Biosciences layoffs (2026)

Avidity Biosciences, a Novartis subsidiary, filed a WARN notice to lay off 40 workers in San Diego. The cuts were set to begin Dec. 31.

Then

The layoffs hit clinical operations, regulatory affairs, and medical writing.

Now

The cuts came eight months after Novartis completed its $12 billion acquisition of Avidity.

Why this matters now

Shows that even acquisition-backed San Diego biotechs are cutting staff.

2026

San Diego County WARN filings (2026)

Employers filed 28 WARN notices in San Diego County covering 1,174 workers at 22 employers as of Nov. 5, 2026.

Then

Cuts spanned biotech, hospitals, airlines, and breweries.

Now

The filings show a broad contraction in the county's workforce.

Why this matters now

Places Crinetics' 78-worker cut in a wider pattern of San Diego layoffs.

Sources

(4)
California Employment Development Department BioSpace Employees First Labor Law San Diego Union-Tribune