Biomedical Research Institute
Appears in 2 stories
Received 2026 AACR Team Science Award for DepMap; poster presented at AACR 2026; awaiting DepMap portal data release for resistance models
Every year, hundreds of thousands of lung cancer patients start treatment with osimertinib, the leading targeted therapy for tumors driven by mutations in the EGFR gene. Most will respond, but nearly all will eventually stop responding as their cancers evolve resistance through a dozen different molecular escape routes. Until now, researchers had to work with messy lab models that made it hard to pin down which genetic change caused which failure.
Updated May 31
Home institution of the DefensePredictor team
Every major tool in genetic engineering — from the enzymes that cut DNA in the 1970s to CRISPR gene editing — started as a defense weapon bacteria use against viruses. Two teams revealed bacteria carry three times more weapons than anyone realized, identifying millions of antiviral proteins from tens of thousands of genomes using machine-learning models that flag a new defense system in five minutes.
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