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Ionis Pharmaceuticals

Ionis Pharmaceuticals

Biotechnology company

Appears in 6 stories · Last updated Oct 29, 2026

Stories

FDA approves first-of-its-kind hepatitis B drug from GSK and Ionis

New Capabilities

Discoverer of bepirovirsen; receives royalties on sales

The Food and Drug Administration approved Hibsago on October 20 for adults with chronic hepatitis B who have no cirrhosis and have taken antiviral pills for at least six months. In two late-stage trials, 19% of patients who took it had no detectable virus 24 weeks after ending all treatment; none of the 614 placebo recipients did.

Updated 7 days ago

Roche's sefaxersen meets phase 3 goal, joining IgAN market battle with Novartis

New Capabilities

As of September 2026: Developer of sefaxersen; partner of Roche

Roche's experimental IgA nephropathy drug sefaxersen met its phase 3 primary endpoint on September 23, cutting proteinuria versus placebo at 37 weeks in the IMAgINATION study. The result, from a prespecified interim look, was strong enough that Roche is taking it to health authorities and planning a medical meeting presentation.

Updated Sep 23

Otsuka, Ionis ALS drug hits primary Phase 3 endpoint, heads to FDA

New Capabilities

As of September 2026: Discovered ulefnersen; co-developing it with Otsuka

FUS-ALS patients have no approved drug targeting the cause of their disease. On September 22, an experimental therapy cleared a key hurdle: a Phase 3 trial showed ulefnersen, an RNA-targeted drug, improved function and survival versus placebo.

Updated Sep 22

FDA approves first Alexander disease treatment, Ionis's Zanvastro

New Capabilities

As of September 2026: Developer of Zanvastro, now launching independently

Jenny Pearson's daughter Elise had her first seizure at 16 months. A scan a year later showed white splotches on her frontal lobe, and a genetic test confirmed Alexander disease, a rare progressive neurological disorder that had no treatment.

Updated Sep 13

Biogen's tau drug slows Alzheimer's decline in first-of-its-kind trial

New Capabilities

As of July 2026: Inventor of the antisense technology, Biogen's partner

For decades, nearly every Alzheimer's drug that reached patients aimed at one target: a sticky protein called amyloid. On July 14, 2026, Biogen showed the first clinical evidence that hitting a different protein, tau, can also slow the disease.

Updated Jul 14

Biogen's salanersen wins FDA breakthrough status for spinal muscular atrophy

New Capabilities

As of June 2026: Discovered salanersen; licensed it to Biogen

Some children with spinal muscular atrophy get a one-time gene therapy, then slowly weaken again. There has been no clear next step for them. On June 4, 2026, the FDA gave Biogen's salanersen a designation meant to speed up that next step.

Updated Jun 4