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Dean Y. Li

Dean Y. Li

President, Merck Research Laboratories

Appears in 1 story

Stories

The first personalized cancer vaccine reaches pivotal testing

New Capabilities

Overseeing Merck's post-Keytruda pipeline strategy

Cancer vaccines have promised to train the immune system against tumors for decades. None has delivered a durable, replicable benefit—until now. On January 20, 2026, Moderna and Merck reported that their personalized mRNA vaccine, combined with the immunotherapy Keytruda, cut the risk of melanoma recurrence or death by 49% at five years in a Phase 2b trial of 157 patients. The sustained result—identical to the three-year mark—suggests the vaccine permanently reprograms immune surveillance rather than offering temporary protection.

Updated Jan 25