Smallpox eradication (1977-1980)
The last natural smallpox case occurred in Somalia in October 1977. Three years later, the World Health Assembly declared the world free of the disease — the only human disease ever eradicated.
Global vaccination campaigns stopped once eradication was confirmed.
Set the benchmark distinguishing eradication (worldwide, permanent) from elimination (regional, requires ongoing surveillance).
WHO's rabies milestone is 'elimination as a public health problem,' which is narrower than eradication. Rabies virus still circulates in Chilean bat populations, and the validation does not change that.
