Largest-ever comparative genomics study finds 11 independent terrestrialization events converged on similar genetic solutions
November 12th, 2025: 154-Genome Terrestrialization Study PublishedNew here? Follow stories to track developments over time. Create a free account to get updates when stories you care about change.
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Evolution of Land Animals - KidsPressMagazine.com
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First terrestrial animals shuffled onto land
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"Evolution, it seems, is rather like the New York literary set—limited imagination, endless repetition, and an annoying tendency to arrive at the same tedious conclusions no matter how many millions of years you give them to think of something original."
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A major UK research university whose School of Biological Sciences led this comparative genomics study.
Spain's largest public university, whose Faculty of Biology and Biodiversity Research Institute co-led this study.
One of the world's most prestigious scientific journals, which published this study on November 12, 2025.
Nature publishes the largest comparative genomics study of land colonization, analyzing 154 genomes across 21 animal phyla and finding strong convergent evolution across 11 independent terrestrialization events.
Special issue in Science presents Zoonomia findings: at least 10% of the human genome is highly conserved across mammals, with convergent evolution in traits like hibernation and brain size.
The Zoonomia consortium releases 240 mammalian genomes, creating a comparative genomics resource that identifies evolutionary constraints and accelerated regions across mammals.
Nature publishes a landmark study showing that echolocating bats and dolphins independently evolved similar mutations in nearly 200 genes, including hearing-related prestin gene.
Simon Conway Morris publishes Life's Solution: Inevitable Humans in a Lonely Universe, arguing that convergent evolution demonstrates evolution's predictability and inevitability.
Stephen Jay Gould argues that evolution is fundamentally contingent in his influential book about the Burgess Shale fossils. The 'tape of life' thought experiment becomes a touchstone for debates about evolutionary predictability.
Discussed by: Evolutionary biologists at Bristol, Barcelona, and genomics research centers
The accumulating evidence for predictable genomic changes across major evolutionary transitions leads to a revised understanding of evolution that emphasizes both contingency and constraint. Textbooks update to present convergence not as a curiosity but as a fundamental principle governing how life responds to environmental challenges.
Discussed by: Comparative genomics researchers and synthetic biologists
Follow-up studies use the convergent gene families identified in this study—particularly those related to osmoregulation and stress response—to develop functional experiments testing their necessity for terrestrial life. This could enable engineering organisms for novel environments.
Discussed by: Astrobiology researchers, NASA, and SETI scientists
If evolution repeatedly arrives at similar solutions on Earth, this strengthens predictions about what traits might arise on other planets with similar environmental pressures. The study's findings inform biosignature research and expectations for extraterrestrial life.
Discussed by: Evolutionary biologists skeptical of convergence claims
Some researchers question whether the convergent patterns reflect true adaptive similarity or methodological artifacts from comparing distantly related genomes. Debate continues about distinguishing genuine convergence from chance similarities in large datasets.
Researchers compared genomes of echolocating bats and dolphins—mammals separated by 80 million years—and found nearly 200 genes with convergent signatures. The hearing gene prestin showed identical amino acid changes in both lineages. Analysis of 805,053 amino acids across 22 mammals revealed convergence was widespread, not restricted to a few genes.
Established that molecular convergence operates at genome-wide scale, not just in isolated cases.
Demonstrated that natural selection can drive identical genetic solutions in response to identical challenges, even across vast evolutionary distances.
This study showed convergence in a single trait (echolocation); the new terrestrialization study extends the principle to an entire lifestyle transition across 11 lineages.
An international consortium sequenced and compared 240 mammalian genomes, representing more than 80% of mammalian families. The project identified that at least 10% of the human genome is conserved across all mammals, pinpointed regions associated with exceptional traits like hibernation, and linked mutations to human diseases.
Created a publicly available resource enabling researchers to identify conserved and rapidly evolving genomic regions.
Established comparative genomics at scale as a standard tool for understanding evolutionary constraints and adaptations.
Zoonomia compared mammals; the new study expands comparative genomics to span 21 animal phyla, enabling detection of convergence across the animal kingdom.
Paleontologist Stephen Jay Gould published Wonderful Life, using the bizarre Cambrian fossils of the Burgess Shale to argue that evolution is fundamentally unpredictable. His thought experiment—'replay the tape of life and outcomes would differ every time'—became the central metaphor for evolutionary contingency.
The book became a bestseller and finalist for the Pulitzer Prize, reshaping public understanding of evolution.
Sparked a 35-year scientific debate between contingency and convergence camps that continues today.
The new study provides the most comprehensive genomic evidence yet for the convergence position, though researchers emphasize that both forces shape evolutionary outcomes.
