Pig kidneys bridge first patients to human transplants
New CapabilitieseGenesis reports five patients treated with engineered pig kidneys; two went on to receive human donor organs
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Overview
Updated 1 hour agoTim Andrews went 271 days without dialysis after receiving a genetically engineered pig kidney in January 2025. In January 2026, he received a human donor kidney — the first time a pig organ has bridged a patient to a human transplant.
eGenesis reported on September 4 that five patients have received its EGEN-2784 pig kidneys since March 2024. Three have sustained kidney function beyond eight months, and two have transitioned to human donor kidneys. The company plans a 33-patient trial starting in early 2027.
Why it matters
If pig kidneys can keep patients off dialysis while they wait for human organs, it could change how 800,000 Americans with kidney failure are treated.
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People Involved
Organizations Involved
Biotechnology company developing human-compatible engineered organs to address the global organ shortage.
Health system that performed the EGEN-2784 xenotransplants in collaboration with eGenesis.
U.S. regulatory agency that cleared the RESTORE trial and approved Expanded Access for individual patients.
Timeline
March 2024 September 2026
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eGenesis reports five patients treated; two bridged to human transplants
Latest Clinical updateeGenesis announced that five patients received EGEN-2784 kidneys since March 2024. Three sustained function beyond eight months; two transitioned to human donor kidneys. The Lancet published Andrews' case. FDA cleared the 33-patient RESTORE trial.
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Andrews receives human donor kidney
ProcedureAndrews received a deceased-donor human kidney with immediate graft function and no evidence of sensitization during follow-up.
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Andrews' pig kidney removed after 271 days
Medical eventThe xenotransplant developed microvascular injury and inflammation after immunosuppression was reduced. The kidney was removed; Andrews went on dialysis for 82 days.
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Tim Andrews receives engineered pig kidney
ProcedureAndrews received an EGEN-2784 pig kidney under an FDA Expanded Access Investigational New Drug application. The kidney functioned immediately.
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First pig kidney xenotransplant to living human
Medical milestoneMassachusetts General Hospital performed the world's first porcine kidney xenotransplant to a living human. The patient survived 52 days before death from cardiac causes unrelated to the transplant.
Historical Context
3 moments from history that rhyme with this story — and how they unfolded.
First successful kidney transplant (1954)
Joseph Murray transplanted a kidney between identical twins at Peter Bent Brigham Hospital in Boston, now part of Mass General Brigham. The recipient, Richard Herrick, lived eight more years.
The success proved organ transplantation was possible, leading to the development of immunosuppressive drugs.
Kidney transplantation became the gold standard for end-stage kidney disease, but donor shortages persist.
The same institution that pioneered human kidney transplantation is now testing pig kidneys as a bridge to human transplants.
First human heart transplant (1967)
Christiaan Barnard transplanted a human heart into Louis Washkansky in Cape Town, South Africa. Washkansky lived 18 days before dying of pneumonia.
The procedure sparked global interest, but early survival rates were poor.
Heart transplantation became standard treatment over the following decades, with one-year survival now above 90%.
Early xenotransplants face similar skepticism and technical challenges to early heart transplants, which took years to become routine.
Jarvik-7 artificial heart (1982)
Barney Clark, a 61-year-old dentist, received the Jarvik-7 artificial heart at the University of Utah. He lived 112 days with the device, which was powered by an external air compressor.
Clark died from multiple organ failure, but the device proved mechanical hearts could sustain life.
The Jarvik-7 was later used as a bridge to transplant, and ventricular assist devices became standard for patients awaiting heart transplants.
Like the Jarvik-7, pig kidneys are being tested as a bridge to human transplantation, with the open question of whether they can become destination therapy.
