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The first human bladder transplant

The first human bladder transplant

New Capabilities

UCLA and USC surgeons pioneer a new frontier in organ replacement surgery

June 9th, 2025: OneLegacy Honors Amanda Cordier

Overview

On May 4, 2025, surgeons at UCLA performed the first successful human bladder transplant. Oscar Larrainzar, a 41-year-old father of four who'd spent seven years on dialysis after losing his bladder and both kidneys to cancer, received both organs in an eight-hour procedure. The kidney started producing urine immediately. Two days after going home, Larrainzar urinated on his own for the first time in seven years.

The surgery adds the bladder to the short list of organs humans can transplant—a list that hadn't expanded in decades. For carefully selected patients with 'terminal' bladders (those destroyed by cancer, radiation damage, or severe dysfunction), this opens a route that doesn't exist today: replace the organ instead of reconstructing it from intestinal tissue. But significant unknowns remain, including long-term rejection rates and how much immunosuppression patients will need.

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Key Indicators

8 hours
Surgery duration
Combined kidney-bladder transplant procedure time
7 years
On dialysis
Larrainzar's wait before transplant eligibility
4+ years
Research phase
From first pig studies to human procedure
5 organs
Donor gift
Amanda Cordier donated kidneys, liver, heart, lungs, and bladder
1st
In human history
First successful bladder transplant ever performed

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People Involved

Organizations Involved

Timeline

January 2021 June 2025

11 events Latest: June 9th, 2025 · 1 year ago Showing 8 of 11
Tap a bar to jump to that date
  1. OneLegacy Honors Amanda Cordier

    Latest Commemoration

    OneLegacy publicly recognizes Amanda Cordier's organ donation that enabled the historic transplant.

  2. Success Announced Publicly

    Announcement

    UCLA and USC announce successful first human bladder transplant to scientific and medical communities.

  3. First Independent Urination in Seven Years

    Medical

    Larrainzar urinates on his own for first time since 2018, marking successful bladder function restoration.

  4. Patient Discharged from Hospital

    Medical

    Larrainzar leaves hospital two days after surgery with stable condition and functioning organs.

  5. First Human Bladder Transplant

    Surgery

    Eight-hour surgery at Ronald Reagan UCLA Medical Center successfully transplants bladder and kidney to Oscar Larrainzar.

  6. Kidney Function Restored Immediately

    Medical

    New kidney produces large urine volume immediately; patient requires no dialysis post-surgery; urine drains properly into new bladder.

  7. Amanda Cordier's Organs Matched

    Donation

    OneLegacy matches Amanda Cordier's organs to five recipients, including Oscar Larrainzar for bladder-kidney transplant.

  8. Clinical Trials Launch

    Clinical Trial

    UCLA (NCT06337942) and USC (NCT05462561) launch parallel clinical trials enrolling patients for bladder or kidney-bladder transplants.

  9. Brain-Dead Donor Trials Completed

    Research

    Five successful robotic bladder transplantations performed in heart-beating brain-dead research donors at USC facilities.

  10. Cadaver Practice Surgeries Begin

    Research

    Team completes first robotic bladder retrievals in human cadavers, discovering robotic approach superior for pelvic vascular work.

  11. Bladder Transplant Research Begins

    Research

    Nassiri and Gill initiate four-year research program to develop bladder transplantation techniques, starting with porcine models.

Historical Context

3 moments from history that rhyme with this story — and how they unfolded.

1954

First Successful Kidney Transplant (1954)

Dr. Joseph Murray at Brigham & Women's Hospital transplanted a kidney between identical twin brothers, eliminating rejection risk. The recipient lived eight more years. This established the technical foundation for all future solid organ transplantation, though non-twin transplants remained impossible until immunosuppression drugs were developed in the 1960s.

Then

Proved organ transplantation was surgically feasible and could extend life.

Now

Launched the entire field of transplant medicine; kidney transplants now routine with over 25,000 performed annually in the U.S.

Why this matters now

Like the 1954 kidney breakthrough, the 2025 bladder transplant opens a new category of organ replacement—but faces the same question: can it scale beyond the first success?

1967-1968

First Heart Transplant (1967-1968)

Dr. Christiaan Barnard transplanted the first human heart in Cape Town in December 1967; the patient lived 18 days. Dr. Norman Shumway followed with the first U.S. heart transplant at Stanford in 1968. Early mortality was high due to rejection and infection. Programs nearly shut down until better immunosuppression drugs emerged in the 1980s.

Then

Initial failures nearly ended heart transplantation; only a few centers persisted through the 1970s.

Now

Heart transplants are now routine with over 3,500 performed annually in the U.S. and one-year survival rates above 90%.

Why this matters now

The bladder transplant's immediate success echoes early heart transplant optimism—but that field endured a decade of failure before becoming viable.

1983

First Lung Transplant Success (1983)

Dr. Joel Cooper performed the first successful single lung transplant at Toronto General Hospital after two decades of failed attempts by other surgeons. Previous failures stemmed from poor healing of the bronchial connection and infection. Cooper's technique innovations finally solved these problems.

Then

Patient survived and breathed independently, validating years of experimental work.

Now

Lung transplants now save thousands annually, though they remain the most technically challenging solid organ transplants with highest rejection rates.

Why this matters now

The bladder shares the lung's challenge: constant exposure to bacteria and foreign material (urine vs. air), which may complicate long-term graft survival.

Sources

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