Yamanaka's induced pluripotent stem cells (2006)
Shinya Yamanaka showed that four transcription factors could turn adult mouse fibroblasts back into pluripotent stem cells, capable of becoming any cell type. The finding won him the Nobel Prize in 2012.
Reprogramming became a standard lab technique within years.
Established that cellular identity and age can be reset, spawning the field of cellular reprogramming.
This study is a direct-conversion alternative that skips the pluripotent stage and resets epigenetic age more slowly, offering a different window into the same phenomenon.
