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Mexico approves world's first RNA-based fungicide

Mexico approves world's first RNA-based fungicide

New Capabilities

GreenLight Biosciences' Oifirax silences a powdery mildew gene; a $50M–100M plant is planned in Mexico City

2 days ago: World-first RNA fungicide approval gains international coverage

Overview

Updated 1 hour ago

Mexican grape growers now have the world's first commercially approved RNA-based fungicide. Oifirax, developed by U.S. biotech GreenLight Biosciences, uses double-stranded RNA to silence the CYP51 gene the powdery mildew fungus needs to make ergosterol, a component of fungal cell membranes.

Mexico's health, agricultural, and environmental agencies cleared it August 12 after a nine-month review. GreenLight plans a $50 million to $100 million production plant in Mexico City, betting growers will switch from conventional chemical fungicides to molecules that degrade naturally in the environment.

Why it matters

RNA fungicides could replace conventional chemical sprays with molecules that break down naturally — a shift in how growers fight crop disease.

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Key Indicators

9
Months of Mexican regulatory review for Oifirax
Three federal agencies cleared the product in a process GreenLight called record time.
$50M–100M
Planned investment in Mexico City production plant
Announced alongside the approval; expected to create about 500 specialized jobs.
99%
Fungal control rate with Oifirax
Two liters per hectare control more than 99% of mildew versus roughly 80% with conventional chemistry.
10+
Years of research and development
GreenLight tested the technology in Mexican and California vineyards before approval.

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Timeline

October 2025 September 2026

5 events Latest: 2 days ago
Tap a bar to jump to that date
  1. World-first RNA fungicide approval gains international coverage

    Latest Coverage

    Human Progress reported the milestone, confirming Mexico as the first market to approve an RNA-based fungicide for sale.

  2. Mexico approves Oifirax, world's first RNA biofungicide

    Milestone

    COFEPRIS, SENASICA, and SEMARNAT cleared the product for use against grape powdery mildew after a nine-month review.

  3. GreenLight announces $50M–100M Mexico City production plant

    Business

    The plant would integrate research, mass production, and export, creating about 500 jobs.

  4. Active ingredient named erysichrona

    Regulatory

    The International Organization for Standardization assigned a common name to the double-stranded RNA active ingredient.

  5. GreenLight files for RNA fungicide registration in US, EU, and Brazil

    Regulatory

    The company submitted Oifirax for approval in three major markets ahead of Mexico's decision.

Historical Context

3 moments from history that rhyme with this story — and how they unfolded.

May 1994

Flavr Savr tomato (1994)

The Flavr Savr tomato became the first genetically engineered food approved by the U.S. Food and Drug Administration. It carried an antisense gene that slowed fruit softening, letting tomatoes ripen on the vine before shipping.

Then

Flavr Savr sold in U.S. supermarkets but failed commercially because of costs and bruising; its developer, Calgene, was later acquired by Monsanto.

Now

The approval opened the path for Roundup Ready soybeans and other engineered crops that now cover a large share of global farmland.

Why this matters now

Like Oifirax, Flavr Savr was the first commercial approval of a wholly new crop-technology class. Its history shows a regulatory green light and market success are different things.

March 2002

Bt cotton in India (2002)

India approved the first genetically modified Bacillus thuringiensis (Bt) cotton, which produces a protein toxic to bollworms. Heated debate over safety and seed pricing preceded rapid farmer adoption.

Then

Bt cotton spread to cover most of India's cotton acreage within a decade, reducing insecticide spraying.

Now

The adoption transformed Indian cotton farming but left lasting disputes over seed costs and farmer debt.

Why this matters now

Shows how a single country's approval of a pest-control technology can rapidly reshape farming practice, and how safety-versus-benefit debates accompany such decisions.

2010s

RNAi insect traits reach the field (2010s)

Crop science companies commercialized the first RNA interference traits, using double-stranded RNA against corn rootworm in insect-protected corn. It was the first field-scale deployment of RNAi in agriculture.

Then

The traits proved RNAi worked in the field against insects and opened the door for regulatory review of other RNA products.

Now

RNAi is now positioned for broader crop protection; Oifirax extends the same gene-silencing mechanism to a fungus.

Why this matters now

Oifirax applies a mechanism already commercialized for insect control to a new pathogen class, following the same regulatory and adoption path.

Sources

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