Human heart can regrow muscle after heart attack, first study shows
New CapabilitiesAustralian researchers overturn the belief that cardiac damage is permanent, opening a path to regenerative heart failure treatments
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Overview
Updated 54 minutes agoMedical textbooks have long said the adult human heart cannot repair itself. Researchers at the University of Sydney, the Baird Institute, and Royal Prince Alfred Hospital have now shown, for the first time in humans, that heart muscle cells regrow after a heart attack.
Using living tissue collected during bypass surgery, the team found that heart muscle cells increase mitosis after a heart attack. The finding, published in Circulation Research, overturns the assumption that damaged heart regions are permanently lost. It opens a new path toward regenerative treatments for heart failure, a condition with no cure short of transplant.
Why it matters
If the heart's natural repair can be amplified, millions of heart failure patients could avoid transplant.
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People Involved
Organizations Involved
Australia's oldest university and the lead institution for the heart regeneration research.
An Australian applied research institute focused on heart and lung disease.
Sydney hospital where bypass patients donated living heart tissue for the study.
Timeline
January 2026 September 2026
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Discovery reaches broad public attention
Today Media coverageScienceDaily, ScienceAlert, and International Business Times cover the finding, bringing the heart regeneration discovery to a global audience.
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Study published in Circulation Research
PublicationThe peer-reviewed study demonstrates increased human cardiomyocyte mitosis after myocardial infarction, confirmed through a novel post-MI biopsy method.
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University of Sydney announces heart regeneration discovery
AnnouncementResearchers reveal that human heart muscle cells regrow after a heart attack, challenging decades of medical doctrine.
Historical Context
2 moments from history that rhyme with this story — and how they unfolded.
Rodent heart regeneration studies (2001–2026)
For 25 years, researchers observed increased mitosis in the heart muscle of mice and rats following induced heart attacks. The increase was real but too small to replace lost tissue, proving adult rodents have an intrinsic regenerative potential.
Animal models became the standard platform for studying cardiac regeneration.
The findings raised the unresolved question of whether human hearts behave the same way — a question the new study answers.
The Australian team confirmed in human tissue what animal studies had shown for a quarter century, closing a major gap between model systems and patients.
Neonatal mouse heart regeneration (2011)
Lineage-tracing experiments showed that neonatal mice regenerate heart muscle after injury. Spared cardiomyocytes near the injury site re-enter the cell cycle and divide to replace lost tissue, rather than a resident stem cell population doing the work.
The discovery reframed the adult heart as having lost, rather than never having had, regenerative capacity.
It motivated a decade of research into restoring that capacity in adult hearts, culminating in the new human evidence.
Showing that young mammalian hearts regenerate raised the possibility that adult humans retain a silenced version of the same program. The new study confirms that program is active, at low levels, even in adults.
