FINGER trial, Finland (2015)
Finnish researchers randomized at-risk older adults to two years of a multidomain program combining diet, exercise, cognitive training and vascular risk monitoring, or to general health advice, and published the results in The Lancet.
The intervention group showed significant gains in processing speed and executive function, the first major RCT to demonstrate the approach.
It became the template for replication trials worldwide, including the U.S. POINTER and LatAm-FINGERS studies.
LatAm-FINGERS adapted the same FINGER design into a Latin American context and reported larger cognitive effects.
