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Ancient tooth proteins suggest link between Homo erectus and modern humans

Ancient tooth proteins suggest link between Homo erectus and modern humans

New Capabilities

Six 400,000-year-old teeth from China carry a mutation shared with Denisovans — and, possibly, with some people alive today

Yesterday: CAS alert on discovery circulates widely

Overview

Updated 50 minutes ago

Six 400,000-year-old Homo erectus teeth from China have yielded the oldest hominin proteins ever recovered in East Asia. The proteins carry two mutations that tie these ancient humans to a single evolutionary lineage, and one of them also appears in Denisovans, an archaic human group that interbred with modern humans.

Chinese Academy of Sciences researchers propose that mutation passed from Homo erectus into Denisovans, then into modern populations in Southeast Asia and Oceania. If correct, it is the first molecular evidence that Homo erectus contributed to the ancestry of living people. Some paleoanthropologists dispute the interpretation, arguing the teeth may actually be Denisovan.

Why it matters

If confirmed, Homo erectus contributed DNA to living humans through Denisovans — rewriting the human family tree.

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Key Indicators

6
Homo erectus teeth analyzed
Six teeth from three Chinese fossil sites yielded enamel proteins.
3
Chinese fossil sites sampled
Zhoukoudian (Peking Man), Hexian, and Sunjiadong.
400,000+
Minimum age of the fossils, in years
Oldest hominin proteome recovered in East Asia; the prior record was roughly 160,000 years.
2
Protein mutations identified
AMBN A253G, unique to these H. erectus, and AMBN M273V, shared with Denisovans.

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People Involved

Organizations Involved

Timeline

May 2026 September 2026

3 events Latest: Yesterday
  1. CAS alert on discovery circulates widely

    Latest Announcement

    Chinese Academy of Sciences alert on the teeth findings reaches broader audiences via ScienceDaily and other outlets.

  2. NSFC touts findings as breakthrough

    Statement

    Funding agency highlights the study as clarifying East Asian hominin evolution.

  3. Nature publishes enamel protein study

    Publication

    Fu Qiaomei's team reports proteins from six Homo erectus teeth across three Chinese sites.

Historical Context

3 moments from history that rhyme with this story — and how they unfolded.

1929

Peking Man excavations begin (1929)

Excavations at Zhoukoudian near Beijing, led by Chinese and Western researchers, uncovered skulls and teeth of Homo erectus dating from roughly 700,000 to 200,000 years ago. The site gave East Asian Homo erectus its iconic place in the human story, though the original skulls were lost during the Second World War.

Then

Established Homo erectus as a central chapter in human evolutionary history in Asia.

Now

A century of morphological debate over whether East Asian H. erectus was one lineage or several — a question the new protein data addresses directly.

Why this matters now

Zhoukoudian is one of the three sites in the new study; the same fossils that defined East Asian Homo erectus are now yielding proteomic data.

March 2010

First Denisovan discovery (2010)

A team led by Svante Pääbo at the Max Planck Institute sequenced DNA from a roughly 40,000-year-old finger bone in Siberia's Denisova Cave. The DNA belonged to an unknown hominin group, later named Denisovans, that was neither Neanderthal nor modern human.

Then

Revealed a new archaic human population that had interbred with ancestors of modern Melanesians and other Asian groups.

Now

Established that multiple archaic hominin groups interbred with modern humans, reshaping models of human migration and ancestry.

Why this matters now

Denisovans are the same group the new study proposes interbred with East Asian Homo erectus — a direct sequel to that 2010 discovery.

April 2020

Homo antecessor enamel proteome (2020)

Researchers including Frido Welker recovered dental enamel proteins from an 800,000-year-old Homo antecessor fossil at Atapuerca, Spain, the oldest hominin proteins then known. The work proved proteins can survive far beyond the reach of ancient DNA.

Then

Showed paleoproteomics could recover evolutionary information from fossils too old for DNA.

Now

Opened a new window into deep-time hominin relationships; the new China study extends that record in East Asia to at least 400,000 years.

Why this matters now

The acid-etching technique used on the Chinese teeth builds directly on this protein-recovery breakthrough.

Sources

(9)