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Dry-cleaning chemical linked to triple the risk of liver scarring

Dry-cleaning chemical linked to triple the risk of liver scarring

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Tetrachloroethylene in blood is associated with significant liver fibrosis, the scarring that precedes cirrhosis

Yesterday: Keck Medicine alert republished on ScienceDaily

Overview

Updated 1 hour ago

The solvent that removes grease and stains from dry-cleaned clothes is in the blood of 7% of Americans. A new study finds these people are three times more likely to have significant liver fibrosis - the scarring that precedes cirrhosis and liver cancer.

Researchers at Keck Medicine of USC analyzed blood samples from 1,614 adults in the National Health and Nutrition Examination Survey (NHANES). When PCE breaks down in the liver, its metabolites react with liver cells, triggering inflammation and scar tissue. Each additional nanogram of PCE per milliliter of blood raised the odds of significant fibrosis fivefold.

The finding held after adjusting for alcohol use, metabolic syndrome, and other liver risk factors, pointing to PCE as an independent threat. The Environmental Protection Agency has begun a 10-year phaseout of PCE in dry cleaning, but the chemical remains in spot removers, adhesives, and stainless steel polish - and it lingers in groundwater from past spills.

Why it matters

A chemical in 7% of Americans' blood triples their risk of liver scarring - and the EPA is only now phasing it out.

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Key Indicators

7%
US adults with detectable PCE in blood
From NHANES data collected 2017-2020, roughly 1 in 14 Americans carries the chemical.
3.2x
Odds of significant liver fibrosis with PCE exposure
Adjusted for age, sex, race, education, alcohol use, and metabolic syndrome (95% CI 1.2-8.2).
5.1x
Odds increase per 1 ng/mL of blood PCE
Dose-response relationship: higher PCE concentrations meant higher fibrosis risk (95% CI 1.1-24.3).
1,614
Adults included in the study analysis
NHANES participants aged 20 and older; people with hepatitis and smokers were excluded.
10 years
EPA phaseout timeline for PCE in dry cleaning
The agency also banned or placed workplace controls on other PCE uses.

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People Involved

Organizations Involved

Timeline

January 2017 September 2026

3 events Latest: Yesterday
  1. Keck Medicine alert republished on ScienceDaily

    Latest Statement

    The university's press release on the PCE-liver fibrosis link is redistributed, renewing public attention on the finding.

  2. Liver International publishes the PCE-liver fibrosis study

    Publication

    Keck Medicine researchers report a 3.2x odds of significant liver fibrosis among adults with detectable PCE in blood.

  3. NHANES begins collecting PCE blood measurements

    Data Collection

    The CDC's national health survey starts measuring tetrachloroethylene in participants' blood, a cycle that runs through 2020.

Historical Context

3 moments from history that rhyme with this story — and how they unfolded.

1953-1987

Camp Lejeune water contamination (1953-1987)

PCE and other volatile organic compounds contaminated drinking water wells at Marine Corps Base Camp Lejeune in North Carolina for three decades. Military families drank, bathed, and cooked with the water.

Then

The contamination was discovered in the 1980s and the wells were closed.

Now

The 2022 PACT Act provided disability compensation for affected veterans and families; studies found links to cancers and liver disease.

Why this matters now

Real-world evidence that PCE in drinking water has harmed thousands of Americans, showing the chemical's effects extend well beyond dry-cleaning workers.

January 1974

Vinyl chloride and liver angiosarcoma (1974)

Three workers at B.F. Goodrich's Louisville PVC plant died of angiosarcoma of the liver, an extremely rare cancer. Within months, vinyl chloride was identified as the cause through epidemiological investigation.

Then

The Occupational Safety and Health Administration issued an emergency temporary standard capping worker exposure.

Now

The discovery reshaped chemical safety regulation, establishing the precedent that industrial chemicals can cause liver disease even at previously 'acceptable' exposure levels.

Why this matters now

A direct precedent: liver disease traced to an industrial chemical, leading to federal action. The PCE finding is an earlier stage - fibrosis precedes cancer.

1940s-1950s

Carbon tetrachloride in dry cleaning (1940s-1950s)

Carbon tetrachloride was the original dry-cleaning solvent, used widely from the 1930s. By the 1940s, it was recognized as a potent hepatotoxin causing liver necrosis in workers and consumers who used it in home spot removers.

Then

The industry replaced carbon tetrachloride with PCE, which was marketed as a safer alternative.

Now

Carbon tetrachloride became one of the most tightly restricted chemicals, with production eventually banned under the Montreal Protocol.

Why this matters now

This is the exact pattern repeating: one chlorinated solvent was swapped for PCE because of liver toxicity, and PCE is now under the same scrutiny.

Sources

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