Convection-enhanced delivery for brain tumors
Surgeons began infusing chemotherapy directly into the brain to bypass the blood-brain barrier, using bulk flow rather than passive diffusion to spread drugs over a wider area. The aim was to reach tumor cells that surgery and systemic drugs missed.
Early studies showed wider drug distribution, but clinical benefit in glioblastoma remained modest. Many drugs still clustered near the catheter tip.
Convection-enhanced delivery remains an active research area and set the template for direct intracranial infusion.
LUCID uses the same direct-infusion idea but adds ultrasound transducers to push drugs farther, directly addressing the technique's main weakness of limited spread.
