Dry-eye serotonin correlation study (2015)
Galor and colleagues measured tear serotonin in 62 patients and found significantly higher levels in those with both dry-eye symptoms and aqueous tear deficiency, compared with symptomatic patients with normal tear production and with controls.
The finding tied tear serotonin to nociceptor sensitization in chronic ocular pain.
It gave tear serotonin a clinical rationale, creating demand for a way to measure it continuously — demand the contact lens now answers.
This study is why the serotonin lens matters: without it, tear serotonin was an interesting molecule with no proven disease link.
